The unfortunate humans that have managed to survive are utterly addicted to genetic enhancements that they once took merely to improve their looks and so on. But in playing around with genetics and trying to improve their physical abilities as well, it's all backfired rather badly - so much so that they've mutated to the extent that they now merely exist to roam the desperate remains of Rapture in search of genetically enhanced material known as ADAM. With killing others and extracting ADAM the only option available to these junkie mutants (like the swift moving Splicers), Rapture is a pretty dangerous, sinister and harrowing place to be - and the perfect setting for a remarkable looking title that you don't mind attributing the wooly next-gen tag to.